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Clin Exp Allergy. 2008 Dec;38(12):1875-81. doi: 10.1111/j.1365-2222.2008.03114.x.

Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis.

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  • 1Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Kanagawa, Japan.

Abstract

BACKGROUND:

IL-33, an IL-1-like cytokine, is a ligand for IL1RL1, which is an important effector molecule of type 2 T helper responses. Although IL-33/IL1RL1 interaction has been suggested to be important in induction of allergic airway inflammation, serum levels of IL-33 and the genetic influences of the polymorphisms of IL-33 in human allergic diseases are unclear.

OBJECTIVE:

The aim of this study was to examine whether the serum IL-33 level and polymorphisms in IL-33 are associated with Japanese cedar (JC) pollinosis, the most common form of allergic rhinitis, and a major public health problem, in Japan.

METHODS:

We performed linkage disequilibrium (LD) mapping of the gene using the HapMap database, and two selected tag single nucleotide polymorphisms were genotyped. We conducted an association study of IL-33 (JC pollinosis, n=170; normal controls, n=100) and measured the IL-33 levels in sera of the 270 subjects by ELISA.

RESULTS:

Serum levels of IL-33 were significantly higher in patients with JC pollinosis (P=0.0018) than in controls. In genetic association analysis, we found a positive association between the polymorphism and JC pollinosis (P=0.048).

CONCLUSION:

Our results support a role for IL-33 in the pathogenesis of JC pollinosis.

[PubMed - indexed for MEDLINE]
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