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FEMS Microbiol Lett. 1991 Jan 15;61(2-3):289-93.

Formation of glycoprotein degrading enzymes by Bacteroides fragilis.

Author information

1
MRC Dunn Clinical Nutrition Centre, Cambridge, U.K.

Abstract

Bacteroides fragilis NCDO 2217 produced a wide range of cell-associated hydrolytic enzymes (neuraminidase, alpha-fucosidase, alpha-N-acetylgalactosaminidase, beta-galactosidase, beta-N-acetylglucosaminidase) that could potentially degrade the carbohydrate moieties of mucin, a complex glycoprotein. The type of substrate used for growth markedly influenced their formation in batch cultures. Synthesis of neuraminidase, alpha-fucosidase, alpha-N-acetylgalactosaminidase and to a lesser extent, beta-N-acetylglucosaminidase, was inversely related to growth rate in continuous cultures (D = 0.03 h-1-0.23 h-1) in which porcine gastric mucin provided the sole source of carbon and nitrogen.

PMID:
1903753
DOI:
10.1016/0378-1097(91)90567-t
[Indexed for MEDLINE]

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