A new cytotoxic friedelane acid--pluricostatic acid--and other compounds from the leaves of Marila pluricostata

Molecules. 2008 Nov 25;13(11):2915-24. doi: 10.3390/molecules13112915.

Abstract

Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2alpha,3beta-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures were elucidated through spectroscopic analysis. The less polar fractions, on GC/MS analysis and comparison with a MS library, resulted in the identification of twenty four sesquiterpenoids. The new triterpenoid acid 1 showed cytotoxicity against the MCF-7, H-460, and SF-268 human cancer cell lines with GI(50) values from 1.2 to 3.3 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Clusiaceae / chemistry*
  • Drug Screening Assays, Antitumor
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Models, Molecular
  • Plant Leaves / chemistry*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • Triterpenes
  • friedoolean-28-oic acid