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J Appl Physiol (1985). 2009 Jan;106(1):326-32. doi: 10.1152/japplphysiol.91353.2008. Epub 2008 Nov 26.

Vascular endothelial senescence: from mechanisms to pathophysiology.

Author information

  • 1Cardiff School of Health Sciences, University of Wales Institute, Cardiff CF5 2YB, UK. jderusalimsky@uwic.ac.uk

Abstract

Most mitotically competent mammalian cell types can react to stress by undergoing a phenotypically distinctive and permanent form of growth arrest called "cellular senescence." This response has been extensively characterized in cell culture and more recently it has been found to occur also in vivo in a number of tissues. In this review I will present the case for the occurrence of senescence in the vascular endothelium. I will also discuss the mechanisms and factors that modulate endothelial cell replicative capacity and the onset of senescence. Finally, I will examine the senescent phenotype and its possible consequences for the development and progression of vascular diseases.

PMID:
19036896
PMCID:
PMC2636933
DOI:
10.1152/japplphysiol.91353.2008
[PubMed - indexed for MEDLINE]
Free PMC Article
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