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Curr Biol. 2008 Nov 25;18(22):R1061-4. doi: 10.1016/j.cub.2008.09.023.

Anion channels: regulation of ClC-3 by an orphan second messenger.

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  • 1Institut für Neurophysiologie, Medizinische Hochschule Hannover, Germany.

Abstract

ClC-3 is a ubiquitously expressed chloride channel isoform whose biological function has been a matter of debate for many years. A recent study reporting its regulation by Ins(3,4,5,6)P(4) assigns novel transport functions and cellular roles to ClC-3 and identifies a regulatory pathway that affects epithelial transport and endosomal pH regulation.

PMID:
19036336
DOI:
10.1016/j.cub.2008.09.023
[PubMed - indexed for MEDLINE]
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