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Aliment Pharmacol Ther. 2009 Feb 1;29(3):308-14. doi: 10.1111/j.1365-2036.2008.03890.x. Epub 2008 Nov 13.

Experience of maintenance infliximab therapy for refractory ulcerative colitis from six centres in England.

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1
Imperial College Healthcare NHS Trust, London, UK.

Abstract

BACKGROUND:

Infliximab is used for treatment of Crohn's disease and, following the Active Ulcerative Colitis Trials (ACT) 1 and 2, it has been used as rescue and maintenance therapy in moderate and severe ulcerative colitis (UC).

AIM:

To report on English experience with maintenance infliximab in terms of response and colectomy rates and side-effect profile in UC.

METHODS:

A retrospective audit conducted by using a web-based questionnaire filled in by 12 gastroenterologists from six English centres.

RESULTS:

Of the 38 patients receiving induction with infliximab, 28 (73.6%) maintained an ongoing response (8-weekly infusions 5 mg/kg) for a mean duration of 16.8 months (range 4-59), with 21 (55.3%) being in remission. Three of 38 patients (7.9%) who also responded had a secondary loss of response after an average of 10 months (range 8-13); seven of 38 patients (18.4%) showed no response. The colectomy rate was seven of 38 (18.4%, five non-responders and two with secondary loss of response). Adverse effects occurred in five patients (13.2%). Two discontinued infliximab (alopecia, invasive breast cancer). The three less-severe adverse effects were acute and delayed-type hypersensitivity reactions and one persistent otitis media.

CONCLUSION:

Our experience suggests acceptable response rates, colectomy rates and side-effect profile of maintenance therapy with infliximab in moderate and severe UC.

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