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Angew Chem Int Ed Engl. 2009;48(13):2359-63. doi: 10.1002/anie.200804689.

A phosphine-mediated conversion of azides into diazo compounds.

Author information

1
Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.

Abstract

N2 the mild: Diazo compounds are extremely versatile intermediates for synthetic organic chemistry, but their synthesis can be challenging in the presence of delicate functional groups. The Staudinger ligation has inspired a mild method for the conversion of a broad range of azides into their diazo compound derivatives through an acyl triazene intermediate.

PMID:
19035612
PMCID:
PMC3128508
DOI:
10.1002/anie.200804689
[Indexed for MEDLINE]
Free PMC Article

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