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Cell Tissue Res. 2009 Feb;335(2):317-21. doi: 10.1007/s00441-008-0724-3. Epub 2008 Nov 26.

Mesenchymal stem cells and skin wound repair and regeneration: possibilities and questions.

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Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical College, General Hospital of PLA, 28 Fu Xing Road, Beijing 100853, PR China.


Adult mesenchymal stem cells (MSCs) have the capacity for self-renewal and for differentiating into a variety of cells and tissues. They may leave their niche to migrate to remote tissues and play a critical role in wound repair and tissue regeneration. Because of their multipotency, easy isolation and culture, highly expansive potential, and immunosuppression properties, these cells may be an attractive therapeutic tool for regenerative medicine and tissue engineering. Several studies have indicated a contribution of MSCs to reconstituting skin in cutaneous wounds, but problems still need resolution before MSCs can be widely used clinically. This review focuses mainly on the benefits of MSCs in skin wound healing and tissue regeneration and on the questions that remain to be answered before MSCs can be used in clinical practice.

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