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Cancer Chemother Pharmacol. 2009 Jul;64(2):317-25. doi: 10.1007/s00280-008-0873-9. Epub 2008 Nov 26.

Gemcitabine and oxaliplatin combination as first-line treatment for advanced pancreatic cancer: a multicenter phase II study.

Author information

1
Division of Hemato-Oncology, College of Medicine, Yeungnam University, Daegu, South Korea.

Abstract

PURPOSE:

Gemcitabine is the only drug approved for single-agent therapy in advanced pancreatic carcinoma (APC). Gemcitabine-based combination chemotherapy has not yet shown promising results.

METHODS:

This multicenter phase II study enrolled previously untreated patients with locally advanced and/or metastatic pancreatic adenocarcinoma. Patients received 1,000 mg/m(2) gemcitabine, 100-min infusion, day 1 and 100 mg/m(2) oxaliplatin, 2-h infusion, day 2; q2w. The primary end point was response rate (RR).

RESULTS:

Thirteen study centers enrolled 48 eligible patients of which 44 were evaluable. The RR, median overall survival, and median time to progression were 18.2%, 9.4 and 5.6 months, respectively. Sixteen patients (36.4%) experienced clinical benefit. The global quality of life scores improved by 11.71. Grade 3/4 peripheral sensory neuropathy was noted (2.1%), while the most common hematologic toxicity was anemia (grade 3/4, 6.3%).

CONCLUSIONS:

Gemcitabine and oxaliplatin combination chemotherapy showed a promising activity in APC patients and was well tolerated.

PMID:
19034448
DOI:
10.1007/s00280-008-0873-9
[Indexed for MEDLINE]

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