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Br J Cancer. 2009 Jan 27;100(2):228-32. doi: 10.1038/sj.bjc.6604801. Epub 2008 Nov 25.

The spliceosome as target for anticancer treatment.

Author information

1
Department of Medical Oncology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Abstract

The spliceosome is a ribonucleoprotein complex involved in RNA splicing, that is, the removal of non-coding introns from precursor messenger RNA. (Alternative) Splicing events may play an essential role in tumourigenesis. The recent discovery that the spliceosome is a target for novel compounds with anticancer activity opens up new therapeutic avenues.

PMID:
19034274
PMCID:
PMC2634708
DOI:
10.1038/sj.bjc.6604801
[Indexed for MEDLINE]
Free PMC Article
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