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J Clin Endocrinol Metab. 2009 Feb;94(2):559-63. doi: 10.1210/jc.2008-1284. Epub 2008 Nov 25.

Vitamin D status and muscle function in post-menarchal adolescent girls.

Author information

1
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom. Kate.Ward@mrc-hnr.cam.ac.uk

Abstract

CONTEXT:

There has been a resurgence of vitamin D deficiency among infants, toddlers, and adolescents in the United Kingdom. Myopathy is an important clinical symptom of vitamin D deficiency, yet it has not been widely studied.

OBJECTIVE:

Our objective was to investigate the relationship of baseline serum 25 hydroxyvitamin D [25(OH)D] concentration and PTH with muscle power and force.

DESIGN:

This was a cross-sectional study.

SETTING:

The study was community based in a secondary school.

PARTICIPANTS:

A total of 99 post-menarchal 12- to 14-yr-old females was included in the study.

MAIN OUTCOME MEASURES:

Jumping mechanography to measure muscle power, velocity, jump height, and Esslinger Fitness Index from a two-legged counter movement jump and force from multiple one-legged hops was performed. Body height, weight, and serum concentrations of 25(OH)D, PTH, and calcium were measured.

RESULTS:

Median serum 25(OH)D concentration was 21.3 nmol/liter (range 2.5-88.5) and PTH 3.7 pmol/liter (range 0.47-26.2). After correction for weight using a quadratic function, there was a positive relationship between 25(OH)D and jump velocity (P = 0.002), jump height (P = 0.005), power (P = 0.003), Esslinger Fitness Index (P = 0.003), and force (P = 0.05). There was a negative effect of PTH upon jump velocity (P = 0.04).

CONCLUSION:

From these data we conclude that vitamin D was significantly associated with muscle power and force in adolescent girls.

Comment in

PMID:
19033372
DOI:
10.1210/jc.2008-1284
[Indexed for MEDLINE]

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