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FEBS Lett. 2008 Dec 24;582(30):4113-6. doi: 10.1016/j.febslet.2008.11.011. Epub 2008 Nov 24.

Beyond HPV: oncomirs as new players in cervical cancer.

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Translational Cancer Research Laboratory, Rajiv Gandhi Center for Biotechnology, Thycaud P.O., Thiruvananthapuram 695 014, Kerala, India.


MicroRNAs (miRNAs) are a recently discovered family of 18-24 nucleotide non-coding RNAs that can negatively regulate target mRNAs. All studied multicellular eukaryotes utilize miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. This review discusses the various cancer-relevant miRNAs (oncomirs) especially in cervical tumorigenesis and the potential role of oncomirs as therapeutic agents and targets for the treatment of cervical cancer.

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