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Nature. 1991 May 9;351(6322):122-7.

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain.

Author information

1
Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla 92093.

Abstract

Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts.

PMID:
1903181
DOI:
10.1038/351122a0
[Indexed for MEDLINE]

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