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Mol Imaging Biol. 2009 Mar-Apr;11(2):64-70. doi: 10.1007/s11307-008-0176-x. Epub 2008 Nov 22.

Diffuse optical tomography of the breast: initial validation in benign cysts.

Author information

  • 1Radiology, University Medical Center Utrecht, Utrecht, the Netherlands. s.m.w.y.vandeven-2@umcutrecht.nl

Abstract

PURPOSE:

The purpose of this study was to validate a newly developed diffuse optical tomography (DOT) system on benign cysts in the breast.

PROCEDURES:

Eight patients with 20 benign cysts were included. Study procedures consisted of optical breast imaging and breast magnetic resonance imaging (MRI) for comparison. A reconstruction algorithm computed three-dimensional images for each of the four near-infrared wavelengths used by our DOT system (Philips Healthcare, Best, The Netherlands). These images were combined using a spectroscopic model to assess tissue composition and lesion size.

RESULTS:

Twenty cysts were analyzed in eight patients. By using the spectroscopic information, 13 of 20 cysts (65%) were visualized with DOT, confirming their high water and low total hemoglobin content. Lesion size and location showed good agreement with MRI; Pearson correlation coefficient was 0.7 (p < 0.01).

CONCLUSIONS:

DOT can visualize benign cysts in the breast and elucidate their high water and low total hemoglobin content by spectroscopic analysis.

PMID:
19030937
PMCID:
PMC2696611
DOI:
10.1007/s11307-008-0176-x
[PubMed - indexed for MEDLINE]
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