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World J Gastroenterol. 2008 Nov 14;14(42):6531-5.

Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: a histopathological review.

Author information

1
Department of Morbid Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Surulere, Lagos, Nigeria. biade64@yahoo.co.uk

Abstract

AIM:

To study the frequency, gender and age distribution as well as pathological characteristics of colorectal carcinoma (CRC) in Lagos and Sagamu in SW Nigeria.

METHODS:

This is a retrospective pathological review of histologically diagnosed CRC from 5 laboratories in Lagos and Sagamu. The clinical data, such as age, sex and clinical summary were extracted from demographic information. Cases of anal cancer were excluded from this study.

RESULTS:

There were 420 cases (237 males and 183 females) of CRC. It peaked in the 60-69 year age group (mean: 50.7; SD: 16.2), M:F ratio 1.3:1 and 23% occurred below 40 years. The majority was well to moderately differentiated adenocarcinoma 321 (76.4%), mucinous carcinoma 45 (10.7%) and signet ring carcinoma 5 (1.2%), and more common in patients under 40 years compared to well differentiated tumors. The recto-sigmoid colon was the most common site (58.6%). About 51% and 34% of cases presented at TNM stages II and III, respectively.

CONCLUSION:

CRC is the commonest malignant gastrointestinal (GIT) tumor most commonly located in the recto-sigmoid region. The age and sex prevalence and histopathological features concur with reports from other parts of the world.

PMID:
19030207
PMCID:
PMC2773341
[Indexed for MEDLINE]
Free PMC Article
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