Format

Send to

Choose Destination
Nat Rev Immunol. 2008 Dec;8(12):958-69. doi: 10.1038/nri2448.

Exploring the full spectrum of macrophage activation.

Author information

1
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA. dmosser@umd.edu

Erratum in

  • Nat Rev Immunol.2010 Jun;10(6):460.

Abstract

Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions. In this Review we suggest a new grouping of macrophage populations based on three different homeostatic activities - host defence, wound healing and immune regulation. We propose that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation. We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations.

PMID:
19029990
PMCID:
PMC2724991
DOI:
10.1038/nri2448
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center