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Nat Biotechnol. 2008 Dec;26(12):1361-3. doi: 10.1038/nbt.1510. Epub 2008 Nov 23.

Recurrent chromosomal abnormalities in human embryonic stem cells.

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1
Department of Embryology and Genetics, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium. laudia.spits@uzbrussel.be

Abstract

Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative genomic hybridization (aCGH) and found that the cells accumulate other recurrent chromosomal abnormalities, including amplification at 20q11.21 and a derivative chromosome 18. These genomic changes have a variable impact at the transcriptional level.

PMID:
19029912
DOI:
10.1038/nbt.1510
[Indexed for MEDLINE]
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