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Lupus. 2008 Dec;17(12):1064-9. doi: 10.1177/0961203308095138.

Peripheral B cell abnormalities and disease activity in systemic lupus erythematosus.

Author information

1
Charite, University Hospital Berlin, Berlin, Germany.

Abstract

Autoreactive B cells and plasma cells appear to be of central importance in the pathogenesis of systemic lupus erythematosus (SLE) characterized by a plethora of autoantibodies. Recent insights into abnormalities of B cell and plasma cell compartments in human SLE have identified a number of cellular disturbances within these compartments that in part correlate with the disease activity. This review discusses these findings and the potential underlying extrinsic and/or intrinsic influences apparently driving general B cell activation in this entity.

PMID:
19029273
DOI:
10.1177/0961203308095138
[Indexed for MEDLINE]

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