Format

Send to

Choose Destination
Med Hypotheses. 2009 Mar;72(3):309-10. doi: 10.1016/j.mehy.2008.08.030. Epub 2008 Nov 22.

Rethinking the stalk effect: a new hypothesis explaining suprasellar tumor-induced hyperprolactinemia.

Author information

1
Department of Zoology, Physiology and Neurobiology Program, University of Wyoming, Dept. 3166, 1000 E University Avenue, Laramie, WY 82071, USA. dcs@uwyo.edu

Abstract

The pars tuberalis is a distinct subdivision of the pituitary gland but its function remains poorly understood. Suprasellar tumors in this pars tuberalis region are frequently accompanied by hyperprolactinemia. As these tumors do not immunoreact for any of the established pituitary hormones, they are classified as nonsecretory. It has been postulated that these suprasellar tumors induce hyperprolactinemia by compressing the pituitary stalk, resulting in impaired dopamine delivery to the pituitary and, consequently, disinhibition of the lactotropes. An alternative hypothesis proposed is that suprasellar tumors secrete a specific pars tuberalis factor that stimulates prolactin secretion. Hypothesized candidates are the preprotachykinin A derived tachykinins, substance P and/or neurokinin A.

PMID:
19028420
PMCID:
PMC2668659
DOI:
10.1016/j.mehy.2008.08.030
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center