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Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. doi: 10.1016/j.bmc.2008.10.090. Epub 2008 Nov 8.

Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.

Author information

1
Department of Chemistry, Virginia Polytechnic Institute and State University, 3111 Hahn Hall, M/C 0212, Blacksburg, VA 24061, USA.

Abstract

Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP-1 in particular are enzymes overexpressed in human cancer cells, and they represent potential molecular targets for novel cancer chemotherapeutic treatments. A number of analogs exhibited significant inhibitory activity against these enzymes, and the bioassay data in addition to structure-activity relationships of these compounds will be discussed.

PMID:
19028102
PMCID:
PMC2860877
DOI:
10.1016/j.bmc.2008.10.090
[Indexed for MEDLINE]
Free PMC Article

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