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Trends Cell Biol. 2009 Jan;19(1):16-23. doi: 10.1016/j.tcb.2008.10.003. Epub 2008 Nov 20.

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development.

Author information

1
Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick, Frederick MD 21702, USA. dmorrison@ncifcrf.gov

Abstract

The highly conserved 14-3-3 protein family has risen to a position of importance in cell biology owing to its involvement in vital cellular processes, such as metabolism, protein trafficking, signal transduction, apoptosis and cell-cycle regulation. The 14-3-3 proteins are phospho-serine/phospho-threonine binding proteins that interact with a diverse array of binding partners. Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phospho-regulatory pathways that are crucial for normal growth and development and that often become dysregulated in human disease states such as cancer. This review examines the recent advances that further elucidate the role of 14-3-3 proteins as integrators of diverse signaling cues that influence cell fate decisions and tumorigenesis.

PMID:
19027299
PMCID:
PMC3073487
DOI:
10.1016/j.tcb.2008.10.003
[Indexed for MEDLINE]
Free PMC Article

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