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Cancer Lett. 2009 Mar 18;275(2):194-7. doi: 10.1016/j.canlet.2008.10.010. Epub 2008 Nov 21.

Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma.

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Department of Internal Medicine II, Klinikum rechts der Isar, University of Munich, Ismaningerstrasse 22, Munich, Germany.


Inappropriate signaling of the RET receptor tyrosine kinase causes different forms of human thyroid malignancy. We have previously identified the adaptor Grap-2 as RET binding protein. To verify involvement of Grap-2 in RET oncogenic signaling we performed sequence and expression analysis of Grap-2 in 15 human MTC samples. All tumors displayed marked Grap-2 mRNA and protein expression without a linear correlation. Beyond one conservative base pair substitution we detected no further alteration in genomic Grap-2 sequence. Consistent Grap-2 expression suggests a specific role for this adaptor in human MTC, while qualitative alterations do not appear to influence RET signaling.

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