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Cancer Lett. 2009 Mar 18;275(2):194-7. doi: 10.1016/j.canlet.2008.10.010. Epub 2008 Nov 21.

Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma.

Author information

1
Department of Internal Medicine II, Klinikum rechts der Isar, University of Munich, Ismaningerstrasse 22, Munich, Germany. leopold.ludwig@lrz.tum.de

Abstract

Inappropriate signaling of the RET receptor tyrosine kinase causes different forms of human thyroid malignancy. We have previously identified the adaptor Grap-2 as RET binding protein. To verify involvement of Grap-2 in RET oncogenic signaling we performed sequence and expression analysis of Grap-2 in 15 human MTC samples. All tumors displayed marked Grap-2 mRNA and protein expression without a linear correlation. Beyond one conservative base pair substitution we detected no further alteration in genomic Grap-2 sequence. Consistent Grap-2 expression suggests a specific role for this adaptor in human MTC, while qualitative alterations do not appear to influence RET signaling.

PMID:
19027225
DOI:
10.1016/j.canlet.2008.10.010
[Indexed for MEDLINE]

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