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J Allergy Clin Immunol. 2009 Jan;123(1):98-104.e1. doi: 10.1016/j.jaci.2008.10.007. Epub 2008 Nov 22.

A novel group of rhinoviruses is associated with asthma hospitalizations.

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1
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232-9500, USA. eva.k.miller@vanderbilt.edu

Abstract

BACKGROUND:

Although recent studies have identified new group C human rhinoviruses (HRVCs), their spectrum of pediatric disease is unknown.

OBJECTIVE:

We sought to determine the presentation and burden of disease caused by HRVCs among young hospitalized children.

METHODS:

We conducted prospective population-based surveillance in 2 US counties among children less than 5 years of age hospitalized with acute respiratory illness or fever from October 2001 through September 2003. Nasal/throat swabs were obtained and tested for HRVs, as determined by means of RT-PCR and then characterized by means of partial sequencing.

RESULTS:

Of 1052 children enrolled and tested during the 2-year period, 167 (16%) had HRVs detected. Of 147 samples successfully sequenced, 64 were group A HRVs, 6 were group B HRVs, and 77 were HRVCs. Children with HRVCs were significantly more likely than those with group A HRVs to have underlying high-risk conditions, such as asthma (42% vs 23%, P = .023) and to have had a discharge diagnosis of asthma (55% vs 36%, P = .022).

CONCLUSIONS:

Overall, HRVCs were detected in 7% of children hospitalized for fever or respiratory conditions and constituted almost half of all rhinovirus-associated hospitalizations, suggesting that this novel group causes a substantial burden of pediatric disease.

Comment in

PMID:
19027147
DOI:
10.1016/j.jaci.2008.10.007
[Indexed for MEDLINE]
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