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Cancer Detect Prev. 2009;32(4):336-7. doi: 10.1016/j.cdp.2008.10.001. Epub 2008 Nov 20.

Gene expression profile in the peripheral blood of patients with prostate cancer and benign prostatic hyperplasia.

Abstract

BACKGROUND:

Prostate cancer consists of multifactorial and multifocal events, generating differential gene expression in tumor cells.

METHODS:

The molecular profile of 14 gene expression was analyzed through cDNA array in blood samples of patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH).

RESULTS:

Messenger RNA from patient's blood showed significant differences between PCa and BPH groups only for the NOS3 gene, with an occurrence chance for PCa5.8-fold higher than BPH disease.

CONCLUSION:

The NOS3 gene expression in the patient's blood may be used as a putative biomarker for prostate cancer.

PMID:
19026495
DOI:
10.1016/j.cdp.2008.10.001
[Indexed for MEDLINE]
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