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Mol Membr Biol. 2008 Dec;25(8):677-82. doi: 10.1080/09687680802552257.

The structure of the efflux pump AcrB in complex with bile acid.

Author information

1
Division of Molecular Biosciences, Membrane Protein Crystallography Group and Membrane Protein Laboratory, Imperial College, London, UK.

Abstract

Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.

PMID:
19023693
DOI:
10.1080/09687680802552257
[Indexed for MEDLINE]

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