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J Neurooncol. 2009 Mar;92(1):1-6. doi: 10.1007/s11060-008-9734-y. Epub 2008 Nov 21.

Chemotherapy, hormonal therapy, and immunotherapy for recurrent meningiomas.

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  • 1Neurosurgical Research Institute, University of Ioannina School of Medicine, University Campus, and Department of Nuclear Medicine, University Hospital of Ioannina, Ioannina, 45110, Greece. csioka@yahoo.com

Abstract

Meningioma is a common intracranial tumor, originating from the meninges of the skull or spinal canal. Most meningiomas are benign tumors, however atypical or anaplastic tumors can be found in 6% of cases. Patients with asymptomatic small benign meningiomas can be followed without therapy, but in symptomatic patients complete surgical resection should be performed. For recurrent previously resected tumors re-resection is recommended followed by radiotherapy in selected cases. Antiprogesterone treatment can also be considered in recurrent benign meningiomas. Immunotherapy with interferon-alpha and chemotherapy should be reserved for all cases of recurrent meningiomas (benign, atypical, and malignant) when all the standard therapies have failed or contraindicated.

PMID:
19023520
[PubMed - indexed for MEDLINE]
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