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Nat Rev Mol Cell Biol. 2008 Dec;9(12):958-70. doi: 10.1038/nrm2549.

Transcription-coupled DNA repair: two decades of progress and surprises.

Author information

1
Department of Biology, Stanford University, 371 Serra Mall, Stanford, California 94305-5020, USA. hanawalt@stanford.edu

Abstract

Expressed genes are scanned by translocating RNA polymerases, which sensitively detect DNA damage and initiate transcription-coupled repair (TCR), a subpathway of nucleotide excision repair that removes lesions from the template DNA strands of actively transcribed genes. Human hereditary diseases that present a deficiency only in TCR are characterized by sunlight sensitivity without enhanced skin cancer. Although multiple gene products are implicated in TCR, we still lack an understanding of the precise signals that can trigger this pathway. Futile cycles of TCR at naturally occurring non-canonical DNA structures might contribute to genomic instability and genetic disease.

PMID:
19023283
DOI:
10.1038/nrm2549
[Indexed for MEDLINE]

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