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Cold Spring Harb Symp Quant Biol. 2008;73:157-62. doi: 10.1101/sqb.2008.73.017. Epub 2008 Nov 6.

Induced pluripotency of mouse and human somatic cells.

Author information

1
Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Boston, Massachusetts 02114, USA

Abstract

The identification of transcription factors to induce pluripotency directly in somatic cells has given researchers a unique platform on which to dissect the mechanisms underlying epigenetic reprogramming. In addition, induced pluripotent stem (iPS) cells have enabled the derivation of patient-specific cells for the study and potential treatment of a variety of diseases. Here, we discuss recent discoveries in the reprogramming field including work from our own laboratory.

PMID:
19022751
DOI:
10.1101/sqb.2008.73.017
[Indexed for MEDLINE]

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