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Bioorg Med Chem Lett. 2009 Jan 1;19(1):123-6. doi: 10.1016/j.bmcl.2008.11.007. Epub 2008 Nov 6.

3,4-Disubstituted indole acylsulfonamides: a novel series of potent and selective human EP3 receptor antagonists.

Author information

1
Medicinal Chemistry Department, deCODE Chemistry, Inc, Woodridge, IL 60517, USA.

Abstract

A series of potent and selective EP(3) receptor antagonists are described. Utilizing a pharmacophore model developed for the EP(3) receptor, a series of 3,4-disubstituted indoles were shown to be high affinity ligands for this target. These compounds showed high selectivity over IP, FP and other EP receptors and are potent antagonists in functional assays.

PMID:
19022669
DOI:
10.1016/j.bmcl.2008.11.007
[Indexed for MEDLINE]

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