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Ann Thorac Surg. 2008 Dec;86(6):e7-8. doi: 10.1016/j.athoracsur.2008.07.062.

Sirolimus ameliorated post lung transplant chylothorax in lymphangioleiomyomatosis.

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Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan.


We report a successful case of sirolimus treatment for chylous pleural and peritoneal effusions of lymphangioleiomyomatosis after lung transplantation. A 32-year-old woman underwent living donor lung transplantation. Persistent chylous pleural and peritoneal effusions were seen postoperatively. Pleurodesis by intrathoracic injection of OK-432, minomycin, and somatostatine analog failed to control chylous effusions. However, sirolimus treatment reduced the amount of chylous drainage and improved both chylous pleural and peritoneal effusions.

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