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J Biomed Opt. 2008 Jul-Aug;13(4):040503. doi: 10.1117/1.2968260.

Label-free in vivo optical imaging of microvasculature and oxygenation level.

Abstract

The ability to perform high-resolution imaging of microvasculature and its oxygenation is very important in studying early tumor development. Toward this goal, we improved upon our excited state absorption (ESA)-based imaging technique to allow us to not only image hemoglobin directly but also differentiate between oxy- and deoxyhemoglobin in tissue. We demonstrate the separation of arterioles from venules in a live nude mouse ear using our imaging technique.

PMID:
19021307
DOI:
10.1117/1.2968260
[Indexed for MEDLINE]
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