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Hippocampus. 2008;18(12):1314-24. doi: 10.1002/hipo.20500.

Towards a functional organization of the medial temporal lobe memory system: role of the parahippocampal and medial entorhinal cortical areas.

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1
Center for Memory and Brain, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA. hbe@bu.edu

Abstract

Whereas substantial recent evidence has suggested to some that the medial entorhinal cortexá (MEC) plays a specialized role in spatial navigation, here we present evidence consistent with a broader role of the MEC in memory. A consideration of evidence on the anatomy and functional roles of medial temporal cortical areas and the hippocampus, and evidence from recordings from MEC neurons in rats performing a spatial memory task, suggest that the MEC may process information about both spatial and temporal context in support of episodic memory.

PMID:
19021265
PMCID:
PMC2592493
DOI:
10.1002/hipo.20500
[Indexed for MEDLINE]
Free PMC Article
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