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Int Arch Occup Environ Health. 2009 Aug;82(8):961-8. doi: 10.1007/s00420-008-0385-2. Epub 2008 Nov 20.

Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children.

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1
Biomedical Research Group, Hanyang Brain Korea 21, Hanyang University, Seoul, Republic of Korea.

Abstract

OBJECTIVES:

This study was conducted to investigate the dominant sources of the urinary pyrene metabolite, 1-hydroxypyrene glucuronide (1-OHPG), in South Korean children.

METHODS:

Urine samples were collected from 102 non-smoking children (aged 10-14). Urinary 1-OHPG was assayed by synchronous fluorescence spectroscopy, following immuno-affinity purification using monoclonal antibody 8E11. Urinary cotinine, a metabolite of nicotine, was measured by GC/MS. Information on environmental tobacco smoke (ETS) exposure, diet, fuel type for heating home, and other possible sources of PAH exposure was collected by self-administered questionnaires.

RESULTS:

Mean (+/-SE) 1-OHPG levels were 1.64 (+/-0.06) ng/ml (range 0.04-3.27 ng/ml). Two multiple linear regression analyses (differing in how ETS was approximated: by parental smoking or urinary cotinine) revealed a positive association between urinary 1-OHPG levels and parental smoking at home (P = 0.007), log urinary cotinine (P = 0.165), frequent grilled (shell)fish consumption (P = 0.061), and living in a commercial/other zone (P = 0.007) versus a residential or industrial zone. No consistent associations were found between 1-OHPG and the child's sex, grilled meat consumption, or fuels used to heat the home.

CONCLUSIONS:

These results support that ETS, frequent grilled fish consumption, and the ambient environment are important predictors of urinary 1-OHPG levels in South Korean children.

PMID:
19020893
DOI:
10.1007/s00420-008-0385-2
[Indexed for MEDLINE]
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