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J Neurophysiol. 2009 Jan;101(1):31-41. doi: 10.1152/jn.90362.2008. Epub 2008 Nov 19.

Circuits generating corticomuscular coherence investigated using a biophysically based computational model. I. Descending systems.

Author information

1
Institute of Neuroscience, Newcastle University, Henry Wellcome Building, Newcastle upon Tyne, NE2 4HH, UK.

Abstract

Recordings of motor cortical activity typically show oscillations around 10 and 20 Hz; only those at 20 Hz are coherent with electromyograms (EMGs) of contralateral muscles. Experimental measurements of the phase difference between approximately 20-Hz oscillations in cortex and muscle are often difficult to reconcile with the known corticomuscular conduction delays. We investigated the generation of corticomuscular coherence further using a biophysically based computational model, which included a pool of motoneurons connected to motor units that generated EMGs. Delays estimated from the coherence phase-frequency relationship were sensitive to the width of the motor unit action potentials. In addition, the nonlinear properties of the motoneurons could produce complex, oscillatory phase-frequency relationships. This was due to the interaction of cortical inputs to the motoneuron pool with the intrinsic rhythmicity of the motoneurons; the response appeared more linear if the firing rate of motoneurons varied widely across the pool, such as during a strong contraction. The model was able to reproduce the smaller than expected delays between cortex and muscles seen in experiments. However, the model could not reproduce the constant phase over a frequency band sometimes seen in experiments, nor the lack of around 10-Hz coherence. Simple propagation of oscillations from cortex to muscle thus cannot completely explain the observed corticomuscular coherence.

PMID:
19019981
PMCID:
PMC2637020
DOI:
10.1152/jn.90362.2008
[Indexed for MEDLINE]
Free PMC Article

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