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Clin Endocrinol (Oxf). 2009 Aug;71(2):284-90. doi: 10.1111/j.1365-2265.2008.03476.x. Epub 2008 Nov 9.

Apolipoprotein E and paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women.

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1
Second Department of Obstetrics and Gynaecology, University of Athens, Aretaieio Hospital, Athens, Greece. ilambrinoudaki@hotmail.com

Abstract

OBJECTIVE:

Autoimmune thyroiditis and overt or subclinical hypothyroidism have been associated with increased prevalence of cardiovascular disease (CVD).

DESIGN:

Cross-sectional investigation of the association between gene polymorphisms related to CVD with thyroid function and autoimmunity.

PATIENTS:

In total 84 healthy postmenopausal women aged 49-69 years.

MEASUREMENTS:

FT3, FT4, anti-TPO and anti-TG were assessed in the sera of participants. The following polymorphisms were assessed from peripheral lymphocyte DNA: Apolipoprotein E E2/E3/E4, paraoxonase 1 A/B, Glycoprotein IIIa leu33pro, MTHFR ala222val, ApoBarg3500gln, plasminogen activator inhibitor 1 4G/5G, cholesterol 7-alpha hydroxylase A204C and cholesterol ester transfer protein B1/B2.

RESULTS:

A statistically significant correlation was found between Apolipoprotein E and paraoxonase 1 polymorphisms and serum thyroid hormones: carriers of the E2 or E4 allele of the ApoE gene had lower levels of FT4 (P = 0.0005) than women with the E3/E3 genotype. Carriers of the B allele of paraoxonase 1 gene had lower levels of FT3 compared to women with the wild-type genotype (P = 0.047). A statistically significant positive association (P = 0.049) was also observed between anti-TG antibodies and the presence of the E2 allele of the Apolipoprotein E gene.

CONCLUSIONS:

Polymorphisms of apolipoprotein E and paraoxonase 1 are associated with different levels of thyroid hormone and anti-Tg antibody levels in the study population in this pilot study. The mechanism underlying this association remains to be elucidated.

[Indexed for MEDLINE]

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