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Int J Tuberc Lung Dis. 2008 Dec;12(12):1485-8.

Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia.

Author information

1
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands. P.Buijtels@umcutrecht.nl

Abstract

Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).

PMID:
19017462
[Indexed for MEDLINE]

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