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Acta Psychiatr Scand. 2009 Feb;119(2):137-42. doi: 10.1111/j.1600-0447.2008.01283.x. Epub 2008 Nov 11.

Depressive symptoms predispose females to metabolic syndrome: a 7-year follow-up study.

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1
Unit of Family Practice, Central Hospital of Middle Finland, Jyväskylä, Finland.

Abstract

OBJECTIVE:

To evaluate the risk for developing metabolic syndrome when having depressive symptoms.

METHOD:

The prevalence of depressive symptoms and metabolic syndrome at baseline, and after a 7-year follow-up as measured with Beck depression inventory (BDI), and using the modified National Cholesterol Education Program--Adult Treatment Panel III criteria for metabolic syndrome (MetS) were studied in a middle-aged population-based sample (n = 1294).

RESULTS:

The logistic regression analysis showed a 2.5-fold risk (95% CI: 1.2-5.2) for the females with depressive symptoms (BDI >or=10) at baseline to have MetS at the end of the follow-up. The risk was highest in the subgroup with more melancholic symptoms evaluated with a summary score of the melancholic items in BDI (OR 6.81, 95% CI: 2.09-22.20). In men, there was no risk difference.

CONCLUSION:

The higher risks for MetS in females with depressive symptoms at baseline suggest that depression may be an important predisposing factor for the development of MetS.

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