Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18390-5. doi: 10.1073/pnas.0808936105. Epub 2008 Nov 17.

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.

Author information

1
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.

Abstract

The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a new module, a repressor helix built from a family conserved sequence motif, PCFXXLP. Mutations in this repressor helix that are linked with human endocrine disorders dissociate the complex and attenuate Dax-1 function. The structure of the Dax-1:LRH-1 complex provides the molecular mechanism for the function of Dax-1 as a potent transcriptional repressor.

PMID:
19015525
PMCID:
PMC2587556
DOI:
10.1073/pnas.0808936105
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center