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Arch Dermatol. 2008 Nov;144(11):1457-64. doi: 10.1001/archderm.144.11.1457.

Clinical assessment of patients with recalcitrant psoriasis in a randomized, observer-blind, vehicle-controlled trial using indigo naturalis.

Author information

1
Department of Traditional Chinese Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taiwan.

Abstract

OBJECTIVE:

To evaluate the efficacy and safety of treatment with indigo naturalis in patients with recalcitrant plaque-type psoriasis.

DESIGN:

Randomized, observer-blind, vehicle-controlled, intrapatient comparison study.

SETTING:

Ambulatory department of a hospital.

PARTICIPANTS:

Forty-two outpatients with chronic plaque psoriasis were enrolled in the study from May 1, 2004, to April 30, 2005.

INTERVENTION:

The patients applied either indigo naturalis ointment or vehicle ointment topically to each of 2 bilaterally symmetrical psoriatic plaque lesions for 12 weeks (depending on the date of enrollment in the study).

MAIN OUTCOME MEASURES:

The outcomes were assessed using the following criteria: the sum of erythema, scaling, and induration scores and the clearing percentage of the target plaque lesion assessed by 2 blinded observers.

RESULTS:

Significant reductions in the sum of scaling, erythema, and induration scores (P < .001) (mean score, 6.3 after indigo naturalis treatment vs 12.8 in control subjects) and plaque area percentage (P < .001) (mean percentage, 38.5% after indigo naturalis treatment vs 90% in controls) were achieved with topical application of indigo naturalis ointment. Approximately 31 of 42 patients (74%) experienced clearance or near clearance of their psoriasis in the indigo ointment-treated lesion.

CONCLUSION:

Topical indigo naturalis ointment was a novel, safe, and effective therapy for plaque-type psoriasis.

PMID:
19015420
DOI:
10.1001/archderm.144.11.1457
[Indexed for MEDLINE]

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