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J Neuroimmunol. 2009 Jan 3;206(1-2):121-4. doi: 10.1016/j.jneuroim.2008.09.017. Epub 2008 Nov 14.

Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS).

Author information

1
University of California, San Francisco, San Francisco, CA 94110, USA.

Abstract

The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with advanced sALS disease. There was a significant negative relationship between plasma LPS and levels of monocyte/macrophage IL-10 expression in sALS blood. These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS.

PMID:
19013651
PMCID:
PMC2995297
DOI:
10.1016/j.jneuroim.2008.09.017
[Indexed for MEDLINE]
Free PMC Article

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