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Biochem Biophys Res Commun. 2009 Jan 9;378(2):218-23. doi: 10.1016/j.bbrc.2008.11.017. Epub 2008 Nov 14.

Adiponectin stimulates IL-8 production by rheumatoid synovial fibroblasts.

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  • 1Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, 6-11-1 Omori-Nishi, Ota-ku, Tokyo 143-8541, Japan.

Abstract

The adipokines are linked not only to metabolic regulation, but also to immune responses. Adiponectin, but not leptin or resistin induced interleukin-8 production from rheumatoid synovial fibroblasts (RSF). The culture supernatant of RSF treated with adiponectin induced chemotaxis, although adiponectin itself had no such effect. Addition of antibody against adiponectin, and inhibition of adiponectin receptor gene decreased adiponectin-induced IL-8 production. Nuclear translocation of nuclear factor-kappa B was increased by adiponectin. The induction of interleukin-8 was inhibited by mitogen-activated protein kinase inhibitors. These findings suggest that adiponectin contributes to the pathogenesis of rheumatoid arthritis.

PMID:
19013427
DOI:
10.1016/j.bbrc.2008.11.017
[PubMed - indexed for MEDLINE]
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