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Cell. 2008 Nov 14;135(4):594-6. doi: 10.1016/j.cell.2008.10.033.

The safety on the TCR trigger.

Author information

1
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. Prior to activation, basic residues in the cytoplasmic domain of the signaling subunits of the T cell receptor associate with the plasma membrane such that the key signaling tyrosines are sequestered in the bilayer.

PMID:
19013269
PMCID:
PMC2905657
DOI:
10.1016/j.cell.2008.10.033
[Indexed for MEDLINE]
Free PMC Article
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