Abstract
A series of cephalosporins derived from cephalothin containing an ester-linked quinolonyl substituent at the C-10 position (C-10 quinolonyl-cephem esters) has been prepared and evaluated for in vitro antibacterial activity. The C-10 quinolonyl-cephem esters exhibited a broadened spectrum of activity when compared with cephalothin and the corresponding quinolones, including activity against beta-lactamase-producing bacteria.
MeSH terms
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Bacteria / drug effects*
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Cephalothin / analogs & derivatives*
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Cephalothin / chemical synthesis
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Cephalothin / pharmacology
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Enterobacter / drug effects
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Escherichia coli / drug effects
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Esters
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Molecular Structure
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Pseudomonas aeruginosa / drug effects
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Quinolines / chemical synthesis*
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Quinolines / pharmacology
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Staphylococcus aureus / drug effects
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Streptococcus pneumoniae / drug effects
Substances
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Esters
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Quinolines
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Cephalothin