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Acta Otolaryngol. 2009 Apr;129(4):367-71. doi: 10.1080/00016480802510186.

Intranasal Capsicum spray in idiopathic rhinitis: a randomized prospective application regimen trial.

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Department of Otorhinolaryngology - Head & Neck Surgery, San Donato Civil Hospital - ASL 8, Arezzo, Italy.



Local Capsicum oleous nasal spray, 4 microg/puff three times a day for 3 consecutive days, is an efficacious and safe treatment for idiopathic rhinitis (IR). Furthermore, being a natural product, Capsicum oleous nasal spray may be readily available for patients.


To evaluate the efficacy and safety of different therapeutic regimens of Capsicum oleous nasal spray in IR.


A total of 208 patients affected by IR were enrolled in a randomized placebo-controlled trial. Diagnosis of IR was made on the basis of history of nasal obstruction, sneezing and/or rhinorrhoea and after exclusion of other nasal/paranasal anatomic disorders. IR patients were randomized into four groups (groups A, B, and C) receiving increasing doses of Capsicum (1, 2 or 4 microg/puff, respectively) and one group (group D) treated with placebo. Capsicum oleous nasal spray, one puff per nostril, was instilled three times a day at 30 min intervals for 3 consecutive days. Pre- and post-treatment nasal symptoms were evaluated with a daily record chart.


A significant reduction in the frequency of IR symptom was noticed in group C (4 microg/puff, three times a day for 3 consecutive days) vs controls (p=0.003). No significant difference in side effects was recorded in patients receiving Capsicum therapy with respect to controls.

[Indexed for MEDLINE]

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