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J Lipid Res. 2009 Apr;50 Suppl:S237-42. doi: 10.1194/jlr.R800033-JLR200. Epub 2008 Nov 14.

Phospholipase A2 structure/function, mechanism, and signaling.

Author information

1
Department of Chemistry, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0601, USA.

Abstract

Tremendous advances in understanding the structure and function of the superfamily of phospholipase A2 (PLA2) enzymes has occurred in the twenty-first century. The superfamily includes 15 groups comprising four main types including the secreted sPLA2, cytosolic cPLA2, calcium-independent iPLA2, and platelet activating factor (PAF) acetyl hydrolase/oxidized lipid lipoprotein associated (Lp)PLA2. We review herein our current understanding of the structure and interaction with substrate phospholipids, which resides in membranes for a representative of each of these main types of PLA2. We will also briefly review the development of inhibitors of these enzymes and their roles in lipid signaling.

PMID:
19011112
PMCID:
PMC2674709
DOI:
10.1194/jlr.R800033-JLR200
[Indexed for MEDLINE]
Free PMC Article

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