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Maturitas. 2008 Dec 20;61(4):330-3. doi: 10.1016/j.maturitas.2008.09.024. Epub 2008 Nov 17.

Effects of estrogen versus estrogen and progesterone on cortisol and interleukin-6.

Author information

1
School of Sport and Exercise Sciences, University of Birmingham, Birmingham B15 2TT, UK. k.edwards@bham.ac.uk

Abstract

OBJECTIVES:

The purpose of this study was to compare the effects of 3 months of estrogen replacement therapy, estrogen plus progesterone replacement therapy and a placebo, on the resting cortisol and interleukin-6 (IL-6) levels in post-menopausal women.

METHODS:

Forty-three women were randomised to one of three treatment arms: estradiol 2mg/day (ERT), estradiol 2mg/day plus medroxyprogesterone acetate 5mg/day (HRT), or a placebo that was administered orally for 3 months.

RESULTS:

Cortisol levels showed a significant condition by intervention interaction. Post hoc tests showed that ERT significantly increased cortisol levels after treatment compared to baseline, while in the HRT group a trend toward increased cortisol was found. No changes were observed in IL-6 levels.

CONCLUSIONS:

Estrogen administration elevated cortisol levels, but this effect may be moderated by progestins. IL-6 was not altered by ERT or HRT, future studies should consider the interaction of cortisol increases on change in IL-6 expression.

PMID:
19010617
PMCID:
PMC2663529
DOI:
10.1016/j.maturitas.2008.09.024
[Indexed for MEDLINE]
Free PMC Article
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