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Vaccine. 2009 Jan 14;27(3):350-4. doi: 10.1016/j.vaccine.2008.10.070. Epub 2008 Nov 14.

The effect of 23-valent pneumococcal polysaccharide vaccine on immunological priming induced by 7-valent conjugate vaccine in asplenic subjects with beta-thalassemia.

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1st Department of Pediatrics, Division of Infectious Diseases, Aghia Sophia Children's Hospital, Athens University School of Medicine, Thivon and M. Asias St., Goudi, 11527 Athens, Greece.


The effect of the 23-valent pneumococcal polysaccharide vaccine (PPV) on the 7-valent conjugate (PCV) vaccine-induced priming was evaluated in 35 splenectomised beta-thalassemics [median (range) age: 30 (12-41) years] vaccinated with either PCV/PPV or two PCVs 1 month apart, followed by a PPV booster 12 months later. 28/35 had already received 1-3 PPVs in the past. Different schedules induced similar anamnestic responses; however priming for 3/5 serotypes induced by one or two PCVs, was inferior in subjects who had received > or =2 PPVs in the past when compared with 23 aged-matched PPV-naïve beta-thalassemics. One PPV following PCV does not affect PCV priming; multiple PPVs induce hyporesponsiveness for some serotypes in splenectomised subjects with beta-thalassemia.

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