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Kidney Int. 2008 Dec;74(11):1371-3. doi: 10.1038/ki.2008.424.

Expanding targets of vitamin D receptor activation: downregulation of several RAS components in the kidney.

Author information

1
Medical School, University of Tampere, Department of Internal Medicine, Tampere University Hospital, Tampere, Finland. ilkka.porsti@uta.fi

Abstract

Vitamin D receptor (VDR) activation has a beneficial influence on the progression of experimental renal insufficiency, and reduced renal tissue renin expression may play a role in this process. Freundlich and co-workers now report that VDR activation also suppresses the expression of angiotensinogen, angiotensin II type 1 receptor, and renin receptor in the kidneys of 5/6 nephrectomized rats, effects associated with reduced blood pressure and urinary protein excretion and with alleviated renal tissue damage.

PMID:
19008907
DOI:
10.1038/ki.2008.424
[Indexed for MEDLINE]
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