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Nat Rev Microbiol. 2008 Dec;6(12):913-24. doi: 10.1038/nrmicro2015.

The curious case of the tumour virus: 50 years of Burkitt's lymphoma.

Author information

1
Department of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA. david.thorleylawson@tufts.edu

Erratum in

  • Nat Rev Microbiol. 2009 Feb;7(2):172.

Abstract

Burkitt's lymphoma (BL) was first described 50 years ago, and the first human tumour virus Epstein-Barr virus (EBV) was discovered in BL tumours soon after. Since then, the role of EBV in the development of BL has become more and more enigmatic. Only recently have we finally begun to understand, at the cellular and molecular levels, the complex and interesting interaction of EBV with B cells that creates a predisposition for the development of BL. Here, we discuss the intertwined histories of EBV and BL and their relationship to the cofactors in BL pathogenesis: malaria and the MYC translocation.

PMID:
19008891
DOI:
10.1038/nrmicro2015
[Indexed for MEDLINE]

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