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Virology. 2009 Feb 20;384(2):335-44. doi: 10.1016/j.virol.2008.10.006. Epub 2008 Nov 12.

The human papillomavirus E7 oncoprotein.

Author information

1
Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. mdrubin@rics.bwh.harvard.edu

Abstract

The human papillomavirus (HPV) E7 oncoprotein shares functional similarities with such proteins as adenovirus E1A and SV40 large tumor antigen. As one of only two viral proteins always expressed in HPV-associated cancers, E7 plays a central role in both the viral life cycle and carcinogenic transformation. In the HPV viral life cycle, E7 disrupts the intimate association between cellular differentiation and proliferation in normal epithelium, allowing for viral replication in cells that would no longer be in the dividing population. This function is directly reflected in the transforming activities of E7, including tumor initiation and induction of genomic instability.

PMID:
19007963
PMCID:
PMC2661820
DOI:
10.1016/j.virol.2008.10.006
[Indexed for MEDLINE]
Free PMC Article

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